Mechanisms of action

CEREBIOME® mechanisms of action on the Brain-Gut axis

CEREBIOME® health effects are supported by clinical studies, manifested by a significant decrease of psychological stress and its symptoms, such as anger-hostility, in stressed but healthy volunteers and by several mechanistic animal studies, indicating positive effects of the probiotic formula on behavioral signs of anxiety and depression. These pioneering studies paved the way to acquire a better understanding of the mechanisms of action.

  1. CEREBIOME® reduces depression-like behavior as shown in rodent models with the normalization of burying time which is associated with anxiety [Gilbert 2013] and back-to-normal social interaction time with other rats, as well as swimming and learning time [Arsenault-Bréard 2012]
  2. CEREBIOME® helps to preserve normal neuroplasticity and neurogenesis as measured by caspase and BDNF biomarkers in rats [Girard 2009; Gilbert 2013; Malick 2015; Ait-Belgnaoui 2014; Mohammadi 2018]
  3. CEREBIOME® prevents occasional neuroinflammation in the limbic system as shown in the brain region responsible for stress response [Mohammadi 2018]
  4. CEREBIOME® reduces apoptosis in the brain (normally-occurring death of cells as part of growth), a process which depends on an intact vagus nerve [Malick 2015]
  5. CEREBIOME® reduces intestinal inflammation due to stress as measured through the use of biomarkers [Arsenault-Bréard 2012; Malick 2015; Mohammadi 2018]
  6. CEREBIOME® improves intestinal permeability and decrease visceral pain [Arsenault-Bréard 2012; Ait-Belganoui 2018]
  7. CEREBIOME® helps to normalize blood dopamine and norepinephrine levels in rats [Tillman, 2018] and increase neurotransmitter precursors in rats and humans [Tillman 2018; Kazemi 2018]
  8. CEREBIOME® helps maintain healthy cortisol levels as observed in humans [Messaoudi, 2010] and in animals [Ait-Belgnaoui, 2014; Malick, 2015; Ait-Belgnaoui 2018]

Related articles

Girard, S. A., et al. (2009). “Lactobacillus helveticus and Bifidobacterium longum taken in combination reduce the apoptosis propensity in the limbic system after myocardial infarction in a rat model.” Br J Nutr 102(10): 1420-1425.

Arseneault-Breard, J., et al. (2012). “Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model.” Br J Nutr 107(12): 1793-1799

Gilbert, K., et al. (2013). “Attenuation of post-myocardial infarction depression in rats by n-3 fatty acids or probiotics starting after the onset of reperfusion.” Br J Nutr 109(1): 50-56.

Malick, M., et al. (2015). “Vagotomy prevents the effect of probiotics on caspase activity in a model of postmyocardial infarction depression.” Neurogastroenterol Motil 27(5): 663-671.

Ait-Belgnaoui, A., et al. (2014). “Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice.” Neurogastroenterol Motil 26(4): 510-520.

Ait-Belgnaoui, A., et al. (2018). “Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation.” Journal of Neurogastroenterology and Motility 24(1): 138-146.

Mohammadi, G., et al. (2018). “The Effects of Probiotic Formulation Pretreatment (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) on a Lipopolysaccharide Rat Model.” Journal of the American College of Nutrition: 1-9.

Tillmann, S., et al. (2018). “Probiotics Affect One‐Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression.” Molecular nutrition & food research.

Messaoudi, M. L., R., et al. (2010). “Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects.” Br J Nutr 105(5): 755-764.