Mechanisms of action

CEREBIOME® mechanisms of action on the Brain-Gut axis

CEREBIOME® health effects are supported by clinical studies, manifested by a significant decrease of psychological stress and its symptoms, such as anger-hostility, in stressed but healthy volunteers and by several mechanistic animal studies, indicating positive effects of the probiotic formula on behavioral signs of anxiety and depression. These pioneering studies paved the way to acquire a better understanding of the mechanisms of action.

  1. CEREBIOME® reduces depression-like behavior as shown in rodent models with the normalization of burying time which is associated with anxiety [Gilbert 2013] and back-to-normal social interaction time with other rats, as well as swimming and learning time [Arsenault-Bréard 2012]
  2. CEREBIOME® helps to preserve normal neuroplasticity and neurogenesis as measured by caspase and BDNF biomarkers in rats [Girard 2009; Gilbert 2013; Malick 2015; Ait-Belgnaoui 2014; Mohammadi 2018]
  3. CEREBIOME® prevents occasional neuroinflammation in the limbic system as shown in the brain region responsible for stress response [Mohammadi 2018]
  4. CEREBIOME® reduces apoptosis in the brain (normally-occurring death of cells as part of growth), a process which depends on an intact vagus nerve [Malick 2015]
  5. CEREBIOME® reduces intestinal inflammation due to stress as measured through the use of biomarkers [Arsenault-Bréard 2012; Malick 2015; Mohammadi 2018]
  6. CEREBIOME® improves intestinal permeability and decrease visceral pain [Arsenault-Bréard 2012; Ait-Belganoui 2018]
  7. CEREBIOME® helps to normalize blood dopamine and norepinephrine levels in rats [Tillman, 2018] and increase neurotransmitter precursors in rats and humans [Tillman 2018; Kazemi 2018]
  8. CEREBIOME® helps maintain healthy cortisol levels as observed in humans [Messaoudi, 2010] and in animals [Ait-Belgnaoui, 2014; Malick, 2015; Ait-Belgnaoui 2018]